Vasilenko N L, Nevinskiĭ G A
Novosibirsk Institute of Bioorganic Chemistry, Siberian Division, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
Mol Biol (Mosk). 2003 Nov-Dec;37(6):944-60.
DNA repair is of paramount importance to protect the integrity of the cell genome. Over the last decade, DNA repair enzymes have been intensely studied owing to their role in mutagenesis, carcinogenesis, and aging. This led to discoveries of novel enzymes, protein factors as well as their intermolecular complexes involved in the repair process. Alternative pathways of cell response to the same type of damage were identified. Data on the tertiary structure of a number of enzymes and mechanisms of their molecular interaction were obtained. This paper is an overview of latest advances in the research of cell response to DNA damage via direct, base and nucleotide excision, and mismatch DNA repair.
DNA修复对于保护细胞基因组的完整性至关重要。在过去十年中，由于DNA修复酶在诱变、致癌作用和衰老过程中的作用，对其进行了深入研究。这导致发现了参与修复过程的新型酶、蛋白质因子及其分子间复合物。确定了细胞对同一类型损伤的替代反应途径。获得了许多酶的三级结构及其分子相互作用机制的数据。本文概述了细胞通过直接修复、碱基和核苷酸切除以及错配DNA修复对DNA损伤作出反应的研究最新进展。
