Baltatu Ovidiu, Bader Michael
Max-Delbrück Center for Molecular Medicine, Berlin-Buch, Germany.
Neuroendocrinology. 2003 Nov;78(5):253-9. doi: 10.1159/000074446.
The existence of a brain renin-angiotensin system (RAS) was postulated 30 years ago. Since then our knowledge on the biology of the brain RAS has advanced considerably. The brain RAS has been found to be involved in the modulation of cardiovascular and fluid-electrolyte homeostasis, generally complementing the classical roles of the endocrine RAS. The RAS has additionally been implicated in other brain-specific functions, such as memory, cognition and stress. During the last years, the development of transgenic technologies allowed to get further insight into the functionality and relevance of the brain RAS. This paper is attempting to summarize our recent experience from transgenic animals.
30年前人们推测大脑中存在肾素-血管紧张素系统（RAS）。从那时起，我们对大脑RAS生物学的认识有了很大进展。已发现大脑RAS参与心血管和体液电解质稳态的调节，通常补充内分泌RAS的经典作用。RAS还与其他大脑特异性功能有关，如记忆、认知和应激。在过去几年中，转基因技术的发展使我们能够更深入地了解大脑RAS的功能和相关性。本文试图总结我们从转基因动物中获得的最新经验。
