D'Andrea Luca D, Regan Lynne
Institute of Biostructure and Bioimaging, CNR, Via Mezzocannone 6, 80134, Naples, Italy.
Trends Biochem Sci. 2003 Dec;28(12):655-62. doi: 10.1016/j.tibs.2003.10.007.
Tetratrico peptide repeat (TPR) proteins have several interesting properties, including their folding characteristics, modular architecture and range of binding specificities. In the past five years, many 3D structures of TPR domains have been solved, revealing at a molecular level the versatility of this basic fold. Here, we discuss the structure of TPRs and highlight the diversity of arrangements and functions that are associated with these ubiquitous domains. Genomic analyses of the distribution of TPR domains are presented along with implications for protein engineering.
四肽重复序列（TPR）蛋白具有若干有趣的特性，包括其折叠特征、模块化结构和多种结合特异性。在过去五年中，许多TPR结构域的三维结构已得到解析，从分子水平揭示了这种基本折叠的多功能性。在此，我们讨论TPR的结构，并强调与这些普遍存在的结构域相关的排列和功能的多样性。同时还介绍了TPR结构域分布的基因组分析及其对蛋白质工程的意义。
