Endtz Hubert P, van West Hanneke, Godschalk Peggy C R, de Haan Lidewij, Halabi Yaskara, van den Braak Nicole, Kesztyüs Barbara I, Leyde Ewald, Ott Alewijn, Verkooyen Roel, Price Lawrence J, Woodward David L, Rodgers Frank G, Ang C Wim, van Koningsveld Rinske, van Belkum Alex, Gerstenbluth Izzy
Department of Neurology, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
J Clin Microbiol. 2003 Dec;41(12):5588-92. doi: 10.1128/JCM.41.12.5588-5592.2003.
A steady increase in the incidence of Guillain-Barré syndrome (GBS) with a seasonal preponderance, almost exclusively related to Campylobacter jejuni, and a rise in the incidence of laboratory-confirmed Campylobacter enteritis have been reported from Curaçao, Netherlands Antilles. We therefore investigated possible risk factors associated with diarrhea due to epidemic C. jejuni. Typing by pulsed-field gel electrophoresis identified four epidemic clones which accounted for almost 60% of the infections. One hundred six cases were included in a case-control study. Infections with epidemic clones were more frequently observed in specific districts in Willemstad, the capital of Curaçao. One of these clones caused infections during the rainy season only and was associated with the presence of a deep well around the house. Two out of three GBS-related C. jejuni isolates belonged to an epidemic clone. The observations presented point toward water as a possible source of Campylobacter infections.
据荷属安的列斯群岛库拉索岛报告，吉兰-巴雷综合征（GBS）发病率稳步上升，具有季节性优势，几乎完全与空肠弯曲菌有关，且实验室确诊的弯曲菌肠炎发病率也有所上升。因此，我们调查了与空肠弯曲菌流行导致腹泻相关的可能危险因素。通过脉冲场凝胶电泳分型鉴定出四个流行克隆，它们占感染病例的近60%。106例病例纳入病例对照研究。在库拉索岛首府威廉斯塔德的特定地区，流行克隆感染更为常见。其中一个克隆仅在雨季引发感染，且与房屋周围有深井有关。与GBS相关的空肠弯曲菌分离株中，三分之二属于流行克隆。这些观察结果表明水可能是空肠弯曲菌感染的一个来源。
