Xiao L, Gibbs H C, Wallace C R
Department of Animal, Veterinary and Aquatic Sciences, University of Maine, Orono 04469.
Am J Vet Res. 1992 Nov;53(11):2019-22.
Effects of Ostertagia ostertagi infection on secretion of insulin, pancreatic glucagon, cortisol, gastrin, and pepsinogen were studied in calves inoculated with 100,000 (group 1) or 10,000 (group 2) O ostertagi infective larvae weekly for 14 weeks. Plasma insulin concentrations in both inoculated groups were lower than those in a non-infected (group 3) control group. The differences between group 1 and group 3 were significant (P < 0.05) at 2 and 12 weeks after initial inoculation. Plasma pancreatic glucagon and cortisol concentrations of groups 1 and 2 did not differ significantly from those of the control group, although plasma pancreatic glucagon concentration was consistently lower in group-1 calves from 4 weeks to end of the study. Plasma pepsinogen and serum gastrin concentrations also increased significantly (P < 0.05) in both groups that received inoculations. We concluded that decreased plasma insulin concentrations are contributory to changes in postabsorptive protein metabolism, and that serum gastrin concentrations are more representative of the pathologic changes in the abomasum than are plasma pepsinogen concentrations.
研究了奥斯特他线虫感染对每周接种100,000条（第1组）或10,000条（第2组）奥斯特他线虫感染性幼虫，持续14周的犊牛胰岛素、胰高血糖素、皮质醇、胃泌素和胃蛋白酶原分泌的影响。两个接种组的血浆胰岛素浓度均低于未感染（第3组）对照组。初次接种后第2周和第12周，第1组和第3组之间的差异具有统计学意义（P < 0.05）。第1组和第2组的血浆胰高血糖素和皮质醇浓度与对照组无显著差异，尽管从第4周直至研究结束，第1组犊牛的血浆胰高血糖素浓度始终较低。两个接种组的血浆胃蛋白酶原和血清胃泌素浓度也显著升高（P < 0.05）。我们得出结论，血浆胰岛素浓度降低是吸收后蛋白质代谢变化的原因之一，并且血清胃泌素浓度比血浆胃蛋白酶原浓度更能代表皱胃的病理变化。
