Fox M T, Gerrelli D, Pitt S R, Jacobs D E, Gill M, Simmonds A D
Department of Veterinary Pathology, Royal Veterinary College, London.
Res Vet Sci. 1989 Nov;47(3):299-304.
Metabolic effects of a trickle challenge with the equivalent of 10,000 infective Ostertagia ostertagi larvae per day were investigated in 12 calves allocated to infected, pair-fed control or ad libitum-fed control groups. Changes in hormone levels reflecting abomasal, pituitary and pancreatic function were monitored using radioimmunoassay techniques previously validated for use in cattle. A range of metabolic profile parameters and blood metabolites was also measured. Feed intake of the infected calves began to decline as blood gastrin and pepsinogen levels reached a peak. The depression in appetite recorded in this group was responsible for significant increases in plasma urea and non-esterified fatty acid levels and associated with an increase in growth hormone/insulin ratio. No significant difference in glucagon levels was recorded between groups. A decline in blood albumin values was also shown in the infected group and associated with a drop in nitrogen digestibility. A significant depression in circulating calcium levels was related to either the hypoalbuminaemia or impaired mineral absorption in the intestine. A decrease in plasma cholesterol values in the infected group was associated with changes in digestive function.
在12头犊牛中研究了每天相当于10000条感染性奥斯特他线虫幼虫的少量感染挑战的代谢效应，这些犊牛被分配到感染组、配对饲喂对照组或自由采食对照组。使用先前经验证可用于牛的放射免疫分析技术监测反映皱胃、垂体和胰腺功能的激素水平变化。还测量了一系列代谢谱参数和血液代谢物。随着血液胃泌素和胃蛋白酶原水平达到峰值，感染犊牛的采食量开始下降。该组记录的食欲下降导致血浆尿素和非酯化脂肪酸水平显著升高，并与生长激素/胰岛素比值增加有关。各组间胰高血糖素水平无显著差异。感染组的血液白蛋白值也出现下降，并与氮消化率下降有关。循环钙水平的显著降低与低白蛋白血症或肠道矿物质吸收受损有关。感染组血浆胆固醇值的降低与消化功能的变化有关。
