Davis J J
Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR, UK.
Philos Trans A Math Phys Eng Sci. 2003 Dec 15;361(1813):2807-25. doi: 10.1098/rsta.2003.1270.
Biological macromolecules have evolved over many millions of years into structures primed, in some cases, for both specific surface recognition and facile, directional electron tunnelling. The redox-active centres of metalloproteins play a central role in photosynthesis and respiration. The processes by which constructive man-made interfaces to these moieties can be generated have advanced greatly during the past two decades or so. Together with recent advances in molecular manipulation, analyses and lithographic fabrication, this knowledge has led to us to the point where bioelectronic devices can be designed and interrogated with good levels of reproducibility.
生物大分子经过数百万年的进化，形成了在某些情况下既适合特定表面识别又便于进行定向电子隧穿的结构。金属蛋白的氧化还原活性中心在光合作用和呼吸作用中起着核心作用。在过去二十年左右的时间里，生成与这些部分的建设性人造界面的过程取得了巨大进展。结合分子操纵、分析和光刻制造方面的最新进展，这些知识使我们达到了可以设计和以良好的可重复性进行检测生物电子器件的阶段。
