培高利特可诱导大鼠纹状体中的可溶性超氧化物歧化酶。
Pergolide can induce soluble superoxide dismutase in rat striata.
作者信息
Clow A, Hussain T, Glover V, Sandler M, Walker M, Dexter D
机构信息
Division of Biomedical Science, Polytechnic of Central London, United Kingdom.
出版信息
J Neural Transm Gen Sect. 1992;90(1):27-31. doi: 10.1007/BF01250515.
PMID:1466876
Abstract
Pergolide, a dopamine receptor agonist, given daily i.p. for three weeks at 0.04 mg/kg and 0.4 mg/kg, significantly induced soluble (Cu-Zn) superoxide dismutase in the rat striatum, while having no effect on the mitochondrial (Mn) form of the enzyme. Such induction, which can also be effected by (-)-deprenyl, may help to protect against nigrostriatal degeneration.
摘要
培高利特是一种多巴胺受体激动剂，以0.04毫克/千克和0.4毫克/千克的剂量每日腹腔注射给药三周，可显著诱导大鼠纹状体中的可溶性（铜锌）超氧化物歧化酶，而对该酶的线粒体（锰）形式没有影响。这种诱导作用也可由（-）-司来吉兰产生，可能有助于预防黑质纹状体变性。
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