Clow A, Hussain T, Glover V, Sandler M, Dexter D T, Walker M
Division of Medical Science and Psychology, Polytechnic of Central London, United Kingdom.
J Neural Transm Gen Sect. 1991;86(1):77-80. doi: 10.1007/BF01250378.
(-)-Deprenyl (0.25 or 2 mg/kg) or saline was injected daily into male Wistar rats for 3 weeks. The striata were dissected out and soluble and particulate superoxide dismutase activity measured. (-)-Deprenyl at 2 mg/kg induced a significant increase in the soluble but not the particulate form of the enzyme. The possibility that this action contributes to the ability of (-)-deprenyl to retard nigral degeneration in man and prolong life in rats is discussed.
将（-）-司来吉兰（0.25或2毫克/千克）或生理盐水每日注射到雄性Wistar大鼠体内，持续3周。取出纹状体，测量可溶性和颗粒性超氧化物歧化酶活性。2毫克/千克的（-）-司来吉兰可使该酶的可溶性形式显著增加，但颗粒性形式未增加。讨论了这一作用是否有助于（-）-司来吉兰延缓人类黑质变性和延长大鼠寿命的能力。
