Devi B Anitha, Kamalakkannan N, Prince P Stanely Mainzen
Department of Biochemistry, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
Phytother Res. 2003 Dec;17(10):1231-3. doi: 10.1002/ptr.1357.
The present study was designed to evaluate the effect of supplementation of fenugreek leaves, an indigenous plant widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus, in streptozotocin induced diabetic rats. Supplementation of the diet with fenugreek leaves showed a significant effect on hyperglycaemia, hypoinsulinaemia and glycosylated haemoglobin in streptozotocin diabetic rats. Fenugreek leaves improved the body weight and liver glycogen. Fenugreek leaves also showed a significant effect on key carbohydrate metabolic enzymes in diabetic rats. The effect of fenugreek leaves was found to be similar to that of glibenclamide. Thus, fenugreek leaves exhibited antidiabetic action in streptozotocin-induced diabetic rats. Insulin restored all the parameters to near normal levels in diabetic rats.
本研究旨在评估胡芦巴叶（一种在印度阿育吠陀医学中广泛用于治疗糖尿病的本土植物）对链脲佐菌素诱导的糖尿病大鼠的影响。在链脲佐菌素诱导的糖尿病大鼠的饮食中添加胡芦巴叶，对高血糖、低胰岛素血症和糖化血红蛋白有显著影响。胡芦巴叶改善了体重和肝糖原。胡芦巴叶对糖尿病大鼠的关键碳水化合物代谢酶也有显著影响。发现胡芦巴叶的作用与格列本脲相似。因此，胡芦巴叶在链脲佐菌素诱导的糖尿病大鼠中表现出抗糖尿病作用。胰岛素使糖尿病大鼠的所有参数恢复到接近正常水平。
