Maillard Ivan, Adler Scott H, Pear Warren S
Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Immunity. 2003 Dec;19(6):781-91. doi: 10.1016/s1074-7613(03)00325-x.
Notch proteins are used repeatedly to direct developmental cell fate decisions in multiple organs. During hematopoiesis and immune development, Notch is critical for T/B lineage specification and for generation of splenic marginal zone B cells. In early embryonic development, Notch is crucial for generating hematopoietic stem cells. Emerging data suggest that Notch may also modulate the differentiation and activity of peripheral T cells. Understanding the specific regulation of the Notch pathway in different contexts and its interaction with other signaling pathways remains an important challenge to comprehend the full spectrum of Notch effects. In this review, we critically assess recent findings regarding the function of Notch in the hematolymphoid system.
Notch蛋白被反复用于指导多个器官中细胞的发育命运决定。在造血和免疫发育过程中，Notch对于T/B细胞谱系的特化以及脾边缘区B细胞的产生至关重要。在胚胎早期发育中，Notch对于造血干细胞的产生至关重要。新出现的数据表明，Notch也可能调节外周T细胞的分化和活性。了解Notch通路在不同情况下的具体调控及其与其他信号通路的相互作用，仍然是全面理解Notch效应的一项重要挑战。在这篇综述中，我们批判性地评估了关于Notch在血液淋巴系统中功能的最新研究发现。
