Láinez-González Daniel, Serrano-López Juana, Alonso-Dominguez Juan Manuel
Experimental Hematology, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, 28040 Madrid, Spain.
Hematology Department, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, Spain.
Cancers (Basel). 2022 Mar 12;14(6):1459. doi: 10.3390/cancers14061459.
The Notch signaling pathway is fundamental to early fetal development, but its role in acute myeloid leukemia is still unclear. It is important to elucidate the function that contains Notch, not only in acute myeloid leukemia, but in leukemic stem cells (LSCs). LSCs seem to be the principal cause of patient relapse. This population is in a quiescent state. Signaling pathways that govern this process must be understood to increase the chemosensitivity of this compartment. In this review, we focus on the conserved Notch signaling pathway, and its repercussions in hematopoiesis and hematological neoplasia. We found in the literature both visions regarding Notch activity in acute myeloid leukemia. On one hand, the activation of Notch leads to cell proliferation, on the other hand, the activation of Notch leads to cell cycle arrest. This dilemma requires further experiments to be answered, in order to understand the role of Notch not only in acute myeloid leukemia, but especially in LSCs.
Notch信号通路对于胎儿早期发育至关重要，但其在急性髓系白血病中的作用仍不清楚。阐明Notch的功能很重要，这不仅对于急性髓系白血病，而且对于白血病干细胞（LSCs）都是如此。LSCs似乎是患者复发的主要原因。这群细胞处于静止状态。必须了解调控这一过程的信号通路，以提高该细胞群的化疗敏感性。在本综述中，我们聚焦于保守的Notch信号通路及其在造血作用和血液系统肿瘤形成中的影响。我们在文献中发现了关于Notch在急性髓系白血病中活性的两种观点。一方面，Notch的激活导致细胞增殖，另一方面，Notch的激活导致细胞周期停滞。这种困境需要进一步的实验来解答，以便了解Notch不仅在急性髓系白血病中，尤其是在LSCs中的作用。
Zotero 插件