血管紧张素II对大鼠穿梭箱被动回避任务的脑室注射效应

Intracerebroventricular effects of angiotensin II on a step-through passive avoidance task in rats.

作者信息

de Souza F A M, Sanchis-Segura C, Fukada S Y, de Bortoli V C, Zangrossi H, de Oliveira A M

机构信息

Laboratório de Farmacologia, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Brazil.

出版信息

Neurobiol Learn Mem. 2004 Jan;81(1):100-3. doi: 10.1016/j.nlm.2003.08.006.

DOI:10.1016/j.nlm.2003.08.006

PMID:14670364

Abstract

A wealth of evidence indicates that angiotensin II (Ang II) is involved in learning and memory. However, the precise role of this peptide in these cognitive processes is still controversial, with data indicating either an inhibitory or an enhancing action. The present study was designed to further investigate the effects of intracerebroventricular injections of Ang II (0.5, 1 or 3nmol/5microl) on a step-through passive avoidance task in male adult Wistar rats. When administered pretraining, Ang II did not affect the acquisition of passive avoidance, but markedly improved avoidance performance when given before the retrieval test. The latter effect was observed in retest sessions performed up to 72h after training. Administration of the peptide five minutes after training impaired retention of inhibitory avoidance. Therefore, Ang II may exert opposite effects on passive avoidance memory according to its interference with brain mechanisms leading to the storage or retrieval of this aversively motivated task.

摘要

大量证据表明，血管紧张素II（Ang II）与学习和记忆有关。然而，这种肽在这些认知过程中的确切作用仍存在争议，数据表明其具有抑制或增强作用。本研究旨在进一步探讨脑室内注射Ang II（0.5、1或3nmol/5微升）对成年雄性Wistar大鼠穿梭箱被动回避任务的影响。预训练时给予Ang II不影响被动回避的习得，但在检索测试前给予时，能显著提高回避表现。在训练后长达72小时进行的复测中观察到了后一种效应。训练后五分钟给予该肽会损害抑制性回避的记忆保持。因此，Ang II可能根据其对导致这种厌恶性动机任务存储或检索的脑机制的干扰，对被动回避记忆产生相反的影响。