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Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells.

作者信息

Dereuddre-Bosquet Nathalie, Roy Béatrice, Routledge Kate, Clayette Pascal, Foucault Georges, Lepoivre Michel

机构信息

SPI-BIO c/o Service de Neurovirologie, CEA, 92265, Fontenay-aux-Roses, France.

出版信息

Antiviral Res. 2004 Jan;61(1):67-70. doi: 10.1016/j.antiviral.2003.08.002.

DOI:10.1016/j.antiviral.2003.08.002
PMID:14670596
Abstract

Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis.

摘要

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