Brandenburg Klaus, Andrä Jörg, Müller Mareike, Koch Michel H J, Garidel Patrick
Forschungszentrum Borstel, LG Biophysik, Parkallee 10, D-23845 Borstel, Germany.
Carbohydr Res. 2003 Nov 14;338(23):2477-89. doi: 10.1016/j.carres.2003.08.008.
An overview is given on the physicochemical properties of bacterial glycopolymers, i.e., pure oligo- and polysaccharides as well as glycolipids. Data from analysis of the chemical and physicochemical properties of various sugar polymers are summarized. Furthermore, data are presented on the thorough characterization of the most important class of bacterial glycopolymers, the lipopolysaccharides (LPS). These data comprise the chemical characterization, the gel to liquid crystalline phase transition behaviour of their acyl chains, the ultrastructural studies of their morphology, and the investigation of the types of aggregate structures present above the critical micellar concentration (CMC). Furthermore, the relevance of these data with respect to an understanding of the various biological effects elicited by LPS is discussed.
本文综述了细菌糖聚合物的物理化学性质，即纯寡糖和多糖以及糖脂。总结了各种糖聚合物化学和物理化学性质分析的数据。此外，还介绍了关于细菌糖聚合物最重要类别——脂多糖（LPS）的全面表征数据。这些数据包括化学表征、其酰基链从凝胶到液晶相的转变行为、其形态的超微结构研究，以及临界胶束浓度（CMC）以上存在的聚集体结构类型的研究。此外，还讨论了这些数据对于理解LPS引发的各种生物学效应的相关性。
