Blumgart C H, Ryall D, Dennison B, Thompson-Hill L M
Department of Anaesthetics, South Cleveland Hospital, Middlesbrough.
Br J Anaesth. 1992 Nov;69(5):457-60. doi: 10.1093/bja/69.5.457.
We have examined the effect of extradual injection of 0.5% bupivacaine or normal saline on the progression of spinal anaesthesia in 28 patients undergoing Caesearean section. Three groups were studied. Subarachnoid anaesthesia was established in all patients. Group A (n = 10), the control, received no extradural injection for 20 min. Group B (n = 9) received extradural bupivacaine 10 ml and group C (n = 9) received extradual saline 10 ml 5 min after the subarachnoid injection. Sensory levels were compared at 5-min intervals and extension of the block was found to be similar in groups B and C and significantly faster than the control (P < 0.05). The quality of anaesthesia and incidence of adverse effects was similar for all three groups. We conclude that the mechanism of extension of spinal anaesthesia by extradural injection of local anaesthesia is largely a volume effect.
我们研究了对28例行剖宫产术患者硬膜外注射0.5%布比卡因或生理盐水对脊髓麻醉进展的影响。研究分为三组。所有患者均建立蛛网膜下腔麻醉。A组(n = 10)为对照组,20分钟内未进行硬膜外注射。B组(n = 9)在蛛网膜下腔注射后5分钟接受10 ml硬膜外布比卡因,C组(n = 9)接受10 ml硬膜外生理盐水。每隔5分钟比较感觉平面,发现B组和C组的阻滞扩展相似,且明显快于对照组(P < 0.05)。三组的麻醉质量和不良反应发生率相似。我们得出结论,硬膜外注射局部麻醉药延长脊髓麻醉的机制主要是容量效应。