新生儿和婴儿的吗啡代谢
Morphine metabolism in neonates and infants.
作者信息
Choonara I, Lawrence A, Michalkiewicz A, Bowhay A, Ratcliffe J
机构信息
Institute of Child Health, Alder Hey Children's Hospital, Liverpool.
出版信息
Br J Clin Pharmacol. 1992 Nov;34(5):434-7. doi: 10.1111/j.1365-2125.1992.tb05652.x.
Abstract
The metabolism of morphine was studied in seven fullterm neonates and five infants receiving a continuous infusion of morphine. All the patients had detectable plasma concentrations of morphine 3-glucuronide (M3G) and 10 had detectable concentrations of morphine 6-glucuronide (M6G). The mean plasma clearance of morphine was 20.1 ml min-1 kg-1 in neonates and 23.4 ml min-1 kg-1 in the group as a whole. The M3G/morphine ratio (7.3) was higher than that previously reported for preterm neonates (5.0) but lower than that reported for children (23.9).
摘要
对7名足月新生儿和5名持续输注吗啡的婴儿的吗啡代谢情况进行了研究。所有患者的血浆中均可检测到吗啡-3-葡萄糖醛酸苷（M3G）浓度，10名患者的血浆中可检测到吗啡-6-葡萄糖醛酸苷（M6G）浓度。新生儿吗啡的平均血浆清除率为20.1 ml·min⁻¹·kg⁻¹，整个研究组为23.4 ml·min⁻¹·kg⁻¹。M3G/吗啡比值（7.3）高于先前报道的早产儿（5.0），但低于报道的儿童（23.9）。
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