儿童体内的吗啡代谢
Morphine metabolism in children.
作者信息
Choonara I A, McKay P, Hain R, Rane A
机构信息
Division of Clinical Pharmacology, University Hospital, Uppsala, Sweden.
出版信息
Br J Clin Pharmacol. 1989 Nov;28(5):599-604. doi: 10.1111/j.1365-2125.1989.tb03548.x.
Abstract
- The metabolism of morphine was studied in 12 children and nine premature neonates on a continuous infusion of morphine (10-360 micrograms kg-1 h-1). 2. The mean plasma clearance of morphine was significantly higher in children than neonates (25.7 and 4.7 ml min-1 kg-1, respectively) (P less than 0.01). 3. All the neonates and children had detectable concentrations of morphine-3-glucuronide (M3G) in plasma. All the children and five neonates had detectable concentrations of morphine-6-glucuronide (M6G) in plasma or urine. 4. The M3G/morphine ratios in plasma and urine, and M6G/morphine ratios in urine were significantly higher in children than neonates (P less than 0.01), suggesting that morphine glucuronidation capacity is enhanced after the neonatal period. 5. There was no difference in the M3G/M6G ratio in children and neonates, indicating a parallel development of both glucuronidation pathways.
摘要
- 对12名儿童和9名早产新生儿持续输注吗啡（10 - 360微克/千克/小时），研究吗啡的代谢情况。2. 儿童吗啡的平均血浆清除率显著高于新生儿（分别为25.7和4.7毫升/分钟/千克）（P < 0.01）。3. 所有新生儿和儿童血浆中均可检测到吗啡-3-葡萄糖醛酸苷（M3G）的浓度。所有儿童和5名新生儿血浆或尿液中均可检测到吗啡-6-葡萄糖醛酸苷（M6G）的浓度。4. 儿童血浆和尿液中的M3G/吗啡比值以及尿液中的M6G/吗啡比值均显著高于新生儿（P < 0.01），表明新生儿期后吗啡葡萄糖醛酸化能力增强。5. 儿童和新生儿的M3G/M6G比值无差异，表明两种葡萄糖醛酸化途径平行发展。
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