Epple H J, Harms G, Notter M, Husack R, Zeitz M, Schneider T
Medizinische Klinik I, Universitätsklinikum Benjamin Franklin, FU Berlin.
Internist (Berl). 2003 Aug;44(8):1031-6. doi: 10.1007/s00108-003-0980-y.
A 30-year-old homosexual man presented with anemia and a several months history of recurrent fever, night sweats and weakness. His travel history included several stays in mediterranean countries during the recent years. Abdominal ultrasound showed massive splenomegaly, hepatomegaly and abdominal lymphadenopathy. A bone marrow aspirate revealed the presence of numerous Leishmania amastigotes, and bone marrow culture and polymerase chain reaction were also positive for Leishmania. In this case report epidemiological, immunological, diagnostic and therapeutic aspects of HIV-Leishmania coinfection are discussed with special emphasis on the impact of liposomal amphotericin B and highly active antiretroviral therapy on the treatment of HIV-leishmania-coinfection.
一名30岁的同性恋男子出现贫血症状，并有数月反复发热、盗汗和虚弱的病史。他的旅行史包括近年来多次前往地中海国家。腹部超声显示脾脏肿大、肝脏肿大和腹部淋巴结病。骨髓穿刺显示存在大量利什曼原虫无鞭毛体，骨髓培养和聚合酶链反应也显示利什曼原虫呈阳性。在本病例报告中，讨论了HIV-利什曼原虫合并感染的流行病学、免疫学、诊断和治疗方面，特别强调了脂质体两性霉素B和高效抗逆转录病毒疗法对HIV-利什曼原虫合并感染治疗的影响。
