Gonda Kathleen C, Wilcke Jeff R, Crisman Mark V, Ward Daniel L, Robertson John L, Finco Delmar R, Braselton W Emmett
Department of Large Animal Clinical Science, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24060, USA.
Am J Vet Res. 2003 Dec;64(12):1486-90. doi: 10.2460/ajvr.2003.64.1486.
To determine whether pharmacokinetic analysis of data derived from a single i.v. dose of iohexol could be used to predict creatinine clearance and evaluate simplified methods for predicting serum clearance of iohexol with data derived from 2 or 3 blood samples in clinically normal foals.
10 healthy foals.
Serum disposition of iohexol and exogenous creatinine clearance was determined simultaneously in each foal (5 males and 5 females). A 3-compartment model of iohexol serum disposition was selected via standard methods. Iohexol clearance calculated from the model was compared with creatinine clearance. Separate limited-sample models were created with various combinations of sample times from the terminal slope of the plasma versus time profile for iohexol. Correction factors were determined for the limited-sample models, and iohexol clearance calculated via each method was compared with exogenous creatinine clearance by use of method comparison techniques.
Mean exogenous creatinine clearance was 2.17 mL/min/kg. The disposition of iohexol was best described by a 3-compartment open model. Mean clearance value for iohexol was 2.15 mL/min/kg and was not significantly different from mean creatinine clearance. A method for predicting serum iohexol clearance based on a 2-sample protocol (3- and 4-hour samples) was developed.
Iohexol clearance can be used to predict exogenous creatinine clearance and can be determined from 2 blood samples taken after i.v. injection of iohexol. Appropriate correction factors for adult horses and horses with abnormal glomerular filtration rate need to be determined.
确定单次静脉注射碘海醇所得数据的药代动力学分析是否可用于预测肌酐清除率，并评估利用临床正常马驹2或3份血样数据预测碘海醇血清清除率的简化方法。
10匹健康马驹。
在每匹马驹（5匹雄性和5匹雌性）中同时测定碘海醇的血清处置情况和外源性肌酐清除率。通过标准方法选择碘海醇血清处置的三室模型。将模型计算所得的碘海醇清除率与肌酐清除率进行比较。根据碘海醇血浆浓度-时间曲线终末斜率的不同采样时间组合建立单独的有限样本模型。确定有限样本模型的校正因子，并使用方法比较技术将通过每种方法计算所得的碘海醇清除率与外源性肌酐清除率进行比较。
平均外源性肌酐清除率为2.17 mL/（min·kg）。碘海醇的处置情况最好用三室开放模型来描述。碘海醇的平均清除率值为2.15 mL/（min·kg），与平均肌酐清除率无显著差异。开发了一种基于两样本方案（3小时和4小时样本）预测血清碘海醇清除率的方法。
碘海醇清除率可用于预测外源性肌酐清除率，且可在静脉注射碘海醇后通过采集2份血样来确定。需要确定成年马和肾小球滤过率异常马的适当校正因子。
