Prokop'eva V D, Laptev B I, Afanas'ev S A
Biokhimiia. 1992 Sep;57(9):1389-92.
The effect of carnosine (15 mM) on the contractile activity of isolated rat hearts contracting in an isotonic regime (37 degrees C at a 5 Hz stimulation frequency) has been studied. Carnosine added to the perfusing solution had no effect on the contractile activity either in hypoxia or during reoxygenation but decreased it with a simultaneous increase in the coronary flow during reoxygenation. Carnosine inhibited by 60% the lactate dehydrogenase release from cardiac cells. A conclusion is drawn that the protective effect of carnosine is due to its membrane-stabilizing action which is implemented during inhibition of peroxidation of membrane lipids.
研究了肌肽（15 mM）对在等张状态下收缩的离体大鼠心脏（37℃，刺激频率5Hz）收缩活性的影响。添加到灌注液中的肌肽在缺氧或复氧过程中对收缩活性均无影响，但在复氧过程中，随着冠状动脉血流量同时增加，肌肽会降低收缩活性。肌肽抑制心肌细胞乳酸脱氢酶释放60%。得出的结论是，肌肽的保护作用归因于其膜稳定作用，该作用在抑制膜脂质过氧化过程中得以实现。
