Huang Ruoqing, Jaffer Shabnam
Department of Pathology, Mount Sinai Medical Center, One Gustave L. Levy Place, New York, New York 10029, USA.
Acta Cytol. 2003 Nov-Dec;47(6):1123-6. doi: 10.1159/000326662.
Sialoblastoma is a rare, aggressive and potentially malignant perinatal/congenital tumor that recapitulates the developing salivary gland. There is only 1 brief description of the cytologic findings of metastatic sialoblastoma and 1 poorly documented case of lung metastasis in the literature.
A 75-month-old girl with a history of recurrent sialoblastoma initially diagnosed at 21 months and treated with multiple incomplete surgical excisions, chemotherapy and radiation presented with a solitary lung nodule. Imprint smears and frozen section of the mass were diagnostic of metastatic sialoblastoma.
Cytologic features of sialoblastoma showed complete concordance with histology and included the presence of variably arranged, tight, solid clusters of atypical-appearing, basaloidlike cells in a background of dispersed epithelial and myoepithelial cells. The clusters contained admixed benign ductal cells and dense, metachromatic, magenta hyaline globular material with smooth, rounded outlines. The differential diagnoses include neoplasms composed of either basaloid cells and/or admixed hyaline matrix material and included pleomorphic adenoma, basal cell adenoma and adenoid cystic carcinoma. All these neoplasms affect patients in the first 2 years of life, whereas sialoblastoma usually occurs in the first 2 decades of life.
涎母细胞瘤是一种罕见的、侵袭性且具有潜在恶性的围产期/先天性肿瘤，它重现了唾液腺的发育过程。文献中仅有1篇关于转移性涎母细胞瘤细胞学表现的简短描述以及1例记录不完善的肺转移病例。
一名75个月大的女孩，有复发性涎母细胞瘤病史，最初于21个月时被诊断出，接受了多次不完全手术切除、化疗和放疗，现出现一个孤立性肺结节。肿块的印片涂片和冰冻切片诊断为转移性涎母细胞瘤。
涎母细胞瘤的细胞学特征与组织学完全一致，包括在散在的上皮细胞和肌上皮细胞背景中存在排列多样、紧密、实性的非典型基底样细胞簇。这些细胞簇包含混合的良性导管细胞以及致密、异染性、品红色透明球状物质，其轮廓光滑、呈圆形。鉴别诊断包括由基底样细胞和/或混合透明基质物质组成的肿瘤，包括多形性腺瘤、基底细胞腺瘤和腺样囊性癌。所有这些肿瘤均影响2岁以内的患者，而涎母细胞瘤通常发生在20岁以内。
