Dardick Irving, Daley Thomas D, McComb R John
Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jan;109(1):109-16. doi: 10.1016/j.tripleo.2009.07.049. Epub 2009 Oct 31.
Essentially, sialoblastoma is a disease of infancy with the oldest case presenting at 4 years of age. About one third of pediatric sialoblastoma cases will have a cribriform growth pattern. No adult cases have been reported with a specific diagnosis of sialoblastoma. If even focal cribriforming were present, such cases have undoubtedly been diagnosed as adenoid cystic carcinoma. Such was the circumstance in the 3 adult tumors presented in this report. Each case, however, has the primitive histopathology with discrete nests of basaloid tumor cells, associated bilayered ductal structures and the fibromyxoid stroma characteristic for sialoblastoma with its resemblance to fetal salivary gland or salivary gland with arrested development. One key example has 28-year follow-up. Sialoblastoma, whether in a child or adult with or without a cribriform growth pattern, appears to have a more favorable prognosis than adenoid cystic carcinoma. Aspects of the histological differential diagnosis of these 2 tumors are discussed.
本质上，涎母细胞瘤是一种婴儿期疾病，年龄最大的病例为4岁。约三分之一的儿童涎母细胞瘤病例会呈现筛状生长模式。目前尚无明确诊断为涎母细胞瘤的成人病例报道。即便存在局灶性筛状结构，此类病例无疑也会被诊断为腺样囊性癌。本报告中呈现的3例成人肿瘤便是如此情况。然而，每例均具有原始组织病理学特征，即基底样肿瘤细胞呈离散巢状、伴有双层导管结构以及涎母细胞瘤特有的纤维黏液样间质，类似于胎儿唾液腺或发育停滞的唾液腺。一个关键病例有28年的随访记录。涎母细胞瘤，无论患儿还是成人，无论有无筛状生长模式，其预后似乎都比腺样囊性癌更为良好。本文讨论了这两种肿瘤组织学鉴别诊断的相关方面。
