Moineddin Rahim, Upshur Ross EG, Crighton Eric, Mamdani Muhammad
Department of Family and Community Medicine, University of Toronto, 256 McCaul Street, 2nd Floor, Toronto, ON, Canada M5T 2W5.
Popul Health Metr. 2003 Dec 15;1(1):10. doi: 10.1186/1478-7954-1-10.
The study of the seasonal variation of disease is receiving increasing attention from health researchers. Available statistical tests for seasonality typically indicate the presence or absence of statistically significant seasonality but do not provide a meaningful measure of its strength. METHODS: We propose the coefficient of determination of the autoregressive regression model fitted to the data () as a measure for quantifying the strength of the seasonality. The performance of the proposed statistic is assessed through a simulation study and using two data sets known to demonstrate statistically significant seasonality: atrial fibrillation and asthma hospitalizations in Ontario, Canada. RESULTS: The simulation results showed the power of the in adequately quantifying the strength of the seasonality of the simulated observations for all models. In the atrial fibrillation and asthma datasets, while the statistical tests such as Bartlett's Kolmogorov-Smirnov (BKS) and Fisher's Kappa support statistical evidence of seasonality for both, the quantifies the strength of that seasonality. Corroborating the visual evidence that asthma is more conspicuously seasonal than atrial fibrillation, the calculated for atrial fibrillation indicates a weak to moderate seasonality ( = 0.44, 0.28 and 0.45 for both genders, males and females respectively), whereas for asthma, it indicates a strong seasonality ( = 0.82, 0.78 and 0.82 for both genders, male and female respectively). CONCLUSIONS: For the purposes of health services research, evidence of the statistical presence of seasonality is insufficient to determine the etiologic, clinical and policy relevance of findings. Measurement of the strength of the seasonal effect, as can be determined using the technique, is also important in order to provide a robust sense of seasonality.
疾病季节性变化的研究正受到健康研究人员越来越多的关注。现有的季节性统计检验通常表明是否存在具有统计学意义的季节性,但并未提供一种有意义的衡量其强度的方法。
我们提出将拟合数据的自回归回归模型的决定系数()作为量化季节性强度的一种度量。通过模拟研究并使用两个已知具有统计学显著季节性的数据集(加拿大安大略省的房颤和哮喘住院数据)来评估所提出统计量的性能。
模拟结果表明,对于所有模型,在充分量化模拟观测值的季节性强度方面具有功效。在房颤和哮喘数据集中,虽然诸如巴特利特的柯尔莫哥洛夫 - 斯米尔诺夫(BKS)和费舍尔卡方检验等统计检验都支持两者存在季节性的统计证据,但能量化该季节性的强度。从视觉证据来看,哮喘的季节性比房颤更明显,这一点得到了证实。房颤的计算结果表明其季节性为弱到中度(男性和女性的分别为0.44、0.28和0.45),而哮喘的则表明其季节性很强(男性和女性的分别为0.82、0.78和0.82)。
对于卫生服务研究而言,仅存在季节性的统计证据不足以确定研究结果在病因学、临床和政策方面的相关性。使用该技术确定的季节性效应强度的测量对于提供稳健的季节性概念也很重要。