Normolle D P, Brown M B
Department of Biostatistics, University of Michigan, Ann Arbor 48109-2029.
Biometrics. 1994 Sep;50(3):798-812.
Time series that arise from biological experimentation can exhibit seasonality where the lengths of the seasons may vary. In addition, such time series may not be stationary with respect to either mean, variance, or autocorrelation, thus making the usual waveform-fitting techniques inappropriate. An agglomerative clustering algorithm for identifying seasons in such series is proposed, consisting of an initialization step, iterative steps where clusters are combined into larger clusters, and a stopping rule for the iteration. The clusters can be associated with seasons or phases, and biological cycles can be identified from the phases. Results of a simulation and an analysis of luteinizing hormone concentrations are presented.
源于生物学实验的时间序列可能呈现季节性,其中季节长度可能各不相同。此外,此类时间序列在均值、方差或自相关方面可能并非平稳,从而使得常用的波形拟合技术并不适用。本文提出了一种用于识别此类序列中季节的凝聚聚类算法,该算法包括一个初始化步骤、将聚类合并为更大聚类的迭代步骤以及迭代的停止规则。这些聚类可以与季节或阶段相关联,并且可以从这些阶段中识别出生物周期。文中给出了一项模拟结果以及对促黄体生成素浓度的分析。