动力学在别构调节中的作用。
The role of dynamics in allosteric regulation.
作者信息
Kern Dorothee, Zuiderweg Erik R P
机构信息
Department of Biochemistry, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA.
出版信息
Curr Opin Struct Biol. 2003 Dec;13(6):748-57. doi: 10.1016/j.sbi.2003.10.008.
The biomolecular conformational changes often associated with allostery are, by definition, dynamic processes. Recent publications have disclosed the role of pre-existing equilibria of conformational substates in this process. In addition, the role of dynamics as an entropic carrier of free energy of allostery has been investigated. Recent work thus shows that dynamics is pivotal to allostery, and that it constitutes much more than just the move from the 'T'-state to the 'R'-state. Emerging computational studies have described the actual pathways of allosteric change.
根据定义，常与变构效应相关联的生物分子构象变化是动态过程。最近的出版物揭示了构象亚态的预先存在的平衡在此过程中的作用。此外，动力学作为变构自由能的熵载体的作用也已得到研究。因此，最近的研究表明，动力学对变构效应至关重要，并且它所构成的远不止是从“T”态到“R”态的转变。新兴的计算研究已经描述了变构变化的实际途径。
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