Cutuli B F, Lacroze M, Dilhuydy J M, Florentz P, Velten M, Allavena C, De Lafontan B, Resbeut M, Campana F, Graic Y
Centre Paul-Strauss, Strasbourg, France.
Bull Cancer. 1992;79(7):689-96.
Male breast cancer represents about only 1% of all breast cancers. We have analysed a retrospective, multicentric series of 404 patients, initially non-metastatic, with mean age of 63 years. The 5 and 10-year overall survival rates were 65 and 36% respectively. Sixty-eight patients developed secondary cancer. From ten patients who already presented with cancer (2.5%) 3 cases corresponded to prostatic cancer treated by estrogen. Four had synchronous cancer (1%). Three and eight patients respectively had a synchronous and metachronous contralateral breast cancer (2.7% of bilateral cancer). Forty-three other patients (10.6%) developed metachronous cancer. The main tumor types were: prostate (9), lung (6), colon and rectum (6), esophagus (4). Four patients developed various hematologic malignancies and 14 patients, various types of solid tumors. From these 43 patients, 27 died; 19 as a result of secondary cancer. This represents 9% of all deaths among the 404 patients. While the bilateral cancer rate is similar to women, the second cancer rate appears to be higher in men. From hematological malignancies, chemotherapy and radiotherapy do not seem to contribute to this high incidence of second cancer.
男性乳腺癌约占所有乳腺癌的1%。我们分析了一个回顾性、多中心的系列研究，共纳入404例患者，这些患者最初均无转移，平均年龄为63岁。5年和10年总生存率分别为65%和36%。68例患者发生了继发性癌症。在已经患有癌症的10例患者（2.5%）中，3例为接受雌激素治疗的前列腺癌。4例为同步性癌症（1%）。分别有3例和8例患者患有同步性和异时性对侧乳腺癌（占双侧乳腺癌的2.7%）。另外43例患者（10.6%）发生了异时性癌症。主要肿瘤类型为：前列腺癌（9例）、肺癌（6例）、结肠直肠癌（6例）、食管癌（4例）。4例患者发生了各种血液系统恶性肿瘤，14例患者发生了各种类型的实体瘤。在这43例患者中，27例死亡；19例死于继发性癌症。这占404例患者中所有死亡人数的9%。虽然双侧乳腺癌的发生率与女性相似，但男性继发性癌症的发生率似乎更高。在血液系统恶性肿瘤中，化疗和放疗似乎与这种高继发性癌症发生率无关。
