Rare fluctuations of native proteins sampled by equilibrium hydrogen exchange.
作者信息
Vendruscolo Michele, Paci Emanuele, Dobson Christopher M, Karplus Martin
机构信息
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
出版信息
J Am Chem Soc. 2003 Dec 24;125(51):15686-7. doi: 10.1021/ja036523z.
PMID:14677926
Abstract
We present a method for determining the ensembles of native protein structures that result from the large fluctuations of low probability revealed by hydrogen-exchange experiments. The measured protection factors are used to bias Monte Carlo simulations to sample the structures of the exchange competent species. The approach is illustrated by its application to the case of alpha-lactalbumin.
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