Fujita Masaki, Nakao Yoichi, Matsunaga Shigeki, Seiki Motoharu, Itoh Yoshifumi, Yamashita Jun, Van Soest Rob W M, Fusetani Nobuhiro
Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
J Am Chem Soc. 2003 Dec 24;125(51):15700-1. doi: 10.1021/ja038025w.
A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical methods to be an unprecedented structure of 4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4,5-c]pyridin-2-amine.
一种具有抗血管生成活性的新型基质金属蛋白酶（MMP）抑制剂——阿吉拉汀A（1），是从海洋海绵中分离得到的。通过光谱学和化学方法相结合确定了化合物1的结构为一种前所未有的结构，即4-(4,5-二溴-1H-吡咯-2-基)]-1H-咪唑并[4,5-c]吡啶-2-胺。
