天然海洋和陆地化合物作为阿尔茨海默病中基质金属蛋白酶-2（MMP-2）和基质金属蛋白酶-9（MMP-9）的调节剂
Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's Disease.
作者信息
Ciccone Lidia, Vandooren Jennifer, Nencetti Susanna, Orlandini Elisabetta
机构信息
Department of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, University of Leuven, KU Leuven-Herestraat 49-Box 1044, 3000 Leuven, Belgium.
出版信息
Pharmaceuticals (Basel). 2021 Jan 24;14(2):86. doi: 10.3390/ph14020086.
Several studies have reported neuroprotective effects by natural products. A wide range of natural compounds have been investigated, and some of these may play a beneficial role in Alzheimer's disease (AD) progression. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, have been implicated in AD. In particular, MMP-2 and MMP-9 are able to trigger several neuroinflammatory and neurodegenerative pathways. In this review, we summarize and discuss existing literature on natural marine and terrestrial compounds, as well as their ability to modulate MMP-2 and MMP-9, and we evaluate their potential as therapeutic compounds for neurodegenerative and neuroinflammatory diseases, with a focus on Alzheimer's disease.
多项研究报告了天然产物的神经保护作用。人们已经对多种天然化合物进行了研究，其中一些可能在阿尔茨海默病（AD）进展中发挥有益作用。基质金属蛋白酶（MMPs）是一类锌依赖性内肽酶家族，与AD有关。特别是，MMP-2和MMP-9能够触发多种神经炎症和神经退行性途径。在本综述中，我们总结并讨论了有关天然海洋和陆地化合物的现有文献，以及它们调节MMP-2和MMP-9的能力，并评估它们作为神经退行性和神经炎症性疾病治疗化合物的潜力，重点是阿尔茨海默病。
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