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HvrA的无效突变可补偿荚膜红细菌中一个必需的relA/spoT样基因的缺失。

Null mutation of HvrA compensates for loss of an essential relA/spoT-like gene in Rhodobacter capsulatus.

作者信息

Masuda Shinji, Bauer Carl E

机构信息

Laboratory for Photobiology, RIKEN Photodynamics Research Center, Sendai 980-0845, Japan.

出版信息

J Bacteriol. 2004 Jan;186(1):235-9. doi: 10.1128/JB.186.1.235-239.2004.

DOI:10.1128/JB.186.1.235-239.2004
PMID:14679243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC303453/
Abstract

We report that a single relA/spoT-like gene exists on the Rhodobacter capsulatus chromosome, and its mutational loss is lethal. This gene could be mutated only under a mutational background of a null mutation in the nucleoid protein HvrA. This result suggests that there may be a direct link between HvrA-regulated promoters and the ppGpp-related stringent response.

摘要

我们报道，在荚膜红细菌染色体上存在一个单一的relA/spoT样基因，其突变缺失是致死性的。该基因仅在类核蛋白HvrA无效突变的突变背景下才能发生突变。这一结果表明，HvrA调控的启动子与ppGpp相关的严谨反应之间可能存在直接联系。

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