New efficient procedure for the use of diethoxyphosphoryl as a protecting group in the synthesis of polyazamacrocycles. Preparation of polyazacyclophanes derived from resorcinol.

作者信息

Burguete M Isabel, López-Diago Laura, García-España Enrique, Galindo Francisco, Luis Santiago V, Miravet Juan F, Sroczynski Dariusz

机构信息

Departament de Química Inorgànica i Orgànica, ESTCE, Universitat Jaume I, E-12080 Castellón, Spain.

出版信息

J Org Chem. 2003 Dec 26;68(26):10169-71. doi: 10.1021/jo0353381.

DOI:10.1021/jo0353381

PMID:14682718

Abstract

The synthesis of polyazamacrocycles containing an electron-rich aromatic subunit derived from resorcinol is described. The reported synthetic procedure is based on the use of diethoxyphosphoryl (Dep) as an amine protecting group. The new conditions employed for the cyclization reaction allow for a generalized use of Dep in the synthesis of polyazamacrocycles.

摘要