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SWI/SNF和组蛋白乙酰转移酶在酵母葡萄糖可阻遏基因动态转录过程中的作用。

Roles of SWI/SNF and HATs throughout the dynamic transcription of a yeast glucose-repressible gene.

作者信息

Geng Fuqiang, Laurent Brehon C

机构信息

Program in Molecular and Cellular Biology, Department of Microbiology and Immunology, SUNY Downstate Medical Center, Brooklyn, NY, USA.

出版信息

EMBO J. 2004 Jan 14;23(1):127-37. doi: 10.1038/sj.emboj.7600035. Epub 2003 Dec 18.

DOI:10.1038/sj.emboj.7600035
PMID:14685262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1271673/
Abstract

Eucaryotic gene expression requires chromatin-remodeling activities. We show by time-course studies that transcriptional induction of the yeast glucose-regulated SUC2 gene is rapid and shows a striking biphasic pattern, the first phase of which is partly mediated by the general stress transcription factors Msn2p/Msn4p. The SWI/SNF ATP-dependent chromatin-remodeling complex associates with the promoter in a similar biphasic manner and is essential for both phases of transcription. Two different histone acetyltransferases, Gcn5p and Esa1p, enhance the binding of SWI/SNF to the promoter during early transcription and are required for optimal SUC2 induction. Gcn5p is recruited to SUC2 simultaneously with SWI/SNF, whereas Esa1p associates constitutively with the promoter. This study reveals an unusual transcription pattern of a metabolic gene and suggests a novel strategy by which distinct chromatin remodelers cooperate for the dynamic activation of transcription.

摘要

真核基因表达需要染色质重塑活性。我们通过时间进程研究表明，酵母葡萄糖调节的SUC2基因的转录诱导迅速且呈现出显著的双相模式，其第一阶段部分由一般应激转录因子Msn2p/Msn4p介导。SWI/SNF ATP依赖性染色质重塑复合物以类似的双相方式与启动子结合，并且对转录的两个阶段都至关重要。两种不同的组蛋白乙酰转移酶Gcn5p和Esa1p在早期转录过程中增强SWI/SNF与启动子的结合，并且是最佳诱导SUC2所必需的。Gcn5p与SWI/SNF同时被招募到SUC2，而Esa1p则组成性地与启动子结合。这项研究揭示了一个代谢基因的不寻常转录模式，并提出了一种新策略，即不同的染色质重塑因子如何协同作用以实现转录的动态激活。