乙型流感病毒/新加坡/222/79株血凝素基因的完整核苷酸序列及其与乙型流感病毒/李/40株血凝素的比较。
Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 hemagglutinin.
作者信息
Verhoeyen M, Van Rompuy L, Jou W M, Huylebroeck D, Fiers W
出版信息
Nucleic Acids Res. 1983 Jul 25;11(14):4703-12. doi: 10.1093/nar/11.14.4703.
Abstract
The complete nucleotide sequence of the hemagglutinin (HA) gene of the human type B influenza virus B/Singapore/222/79 is presented. Comparison with the only other known sequence of a B hemagglutinin (B/Lee/40) shows that antigenic drift in type B HA genes is essentially the same as already observed within the influenza A H3 subtype, i.e., an accumulation of point mutations. The main difference is that the apparent evolution is significantly slower, most likely due to the cumulative effect of a lower occurrence in the population (slower evolution) and/or less immunological pressure. There is a striking cluster of changes at positions 127 until 137 of the HA1 subunit which may represent one of the antigenic sites of the molecule.
摘要
本文给出了B型流感病毒B/新加坡/222/79血凝素（HA）基因的完整核苷酸序列。与另一个已知的B型血凝素序列（B/李/40）比较表明，B型HA基因中的抗原漂移与甲型流感病毒H3亚型中已观察到的情况基本相同，即点突变的积累。主要区别在于，明显的进化速度明显较慢，最可能的原因是人群中出现频率较低（进化较慢）和/或免疫压力较小的累积效应。在HA1亚基的127至137位有一组显著的变化，这可能代表了该分子的一个抗原位点。
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