Whiteside Theresa L, Odoux Christine
Research Pavilion at the Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Suite 1.27, PA 15213-1863, Pittsburgh, USA.
Cancer Immunol Immunother. 2004 Mar;53(3):240-8. doi: 10.1007/s00262-003-0468-6. Epub 2003 Dec 18.
Dendritic cells (DCs) are nature's best antigen-presenting cells. They possess attributes that allow them to effectively fulfill the requirements for priming/activating T cells and mediating tumor-specific immune responses. In this review, emphasis is placed on those aspects of DC biology that best illustrate their usefulness in immunotherapy of cancer. Culture, maturation, and polarization conditions for human DC are discussed, as are strategies for antigen-loading of DCs and for their delivery to patients with cancer. A concise recommendation for monitoring of DC-based vaccination trails is provided.
树突状细胞（DCs）是自然界中最佳的抗原呈递细胞。它们具有一些特性，使其能够有效地满足启动/激活T细胞以及介导肿瘤特异性免疫反应的要求。在本综述中，重点关注DC生物学中最能说明其在癌症免疫治疗中有用性的那些方面。讨论了人DC的培养、成熟和极化条件，以及DC抗原加载及其递送至癌症患者的策略。还提供了基于DC的疫苗接种试验监测的简要建议。
