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帕金森病患者使用抗帕金森病药物改善睡眠呼吸暂停低通气:一项多导睡眠图研究

Improvement of sleep hypopnea by antiparkinsonian drugs in a patient with Parkinson's disease: a polysomnographic study.

作者信息

Yoshida Tomokatsu, Kono Ichiyo, Yoshikawa Kenji, Hashimoto Hiroaki, Harada Hidehiko, Nakagawa Masanori

机构信息

Department of Neurology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566.

出版信息

Intern Med. 2003 Nov;42(11):1135-8. doi: 10.2169/internalmedicine.42.1135.

Abstract

An 80-year-old man was admitted to our hospital because of bradykinesia, muscle rigidity and respiratory dysfunction during sleep. Concerning bradykinesia and muscle rigidity, we diagnosed him as the early/moderate stage of Parkinson's disease without autonomic dysfunction. Polysomnography (PSG) showed a series of obstructive hypopneas and apneas. After administration of antiparkinsonian drugs, rigidity of the neck and trunk was diminished along with a drastic decrease in hypopnea on PSG. We consider that sleep hypopnea in this patient is caused by involvement of the striated musculature surrounding the upper-airway and/or rigidity in the trunk. These conditions are treatable with antiparkinsonian drugs.

摘要

一名80岁男性因运动迟缓、肌肉僵硬及睡眠期间呼吸功能障碍入住我院。关于运动迟缓和肌肉僵硬,我们将其诊断为帕金森病早期/中期,无自主神经功能障碍。多导睡眠图(PSG)显示一系列阻塞性呼吸浅慢和呼吸暂停。给予抗帕金森病药物后,颈部和躯干的僵硬减轻,同时PSG上的呼吸浅慢显著减少。我们认为该患者的睡眠呼吸浅慢是由上呼吸道周围的横纹肌受累和/或躯干僵硬所致。这些情况可用抗帕金森病药物治疗。

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