帕金森病睡眠障碍的患病率及其相关因素：一项多导睡眠图研究。
Prevalence and correlates of sleep disorders in Parkinson's disease: a polysomnographic study.
作者信息
Alatriste-Booth Vanessa, Rodríguez-Violante Mayela, Camacho-Ordoñez Azyadeh, Cervantes-Arriaga Amin
机构信息
Unidad de Medicina del Sueño, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
Clínica de Trastornos del Movimiento, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
出版信息
Arq Neuropsiquiatr. 2015 Mar;73(3):241-5. doi: 10.1590/0004-282X20140228.
OBJECTIVE
Sleep disorders in Parkinson's disease are very common. Polysomnography (PSG) is considered the gold standard for diagnosis. The aim of the present study is to assess the prevalence of nocturnal sleep disorders diagnosed by polysomnography and to determine the associated clinical factors.
METHOD
A total of 120 patients with Parkinson's disease were included. All patients underwent a standardized overnight, single night polysomnography.
RESULTS
Ninety-four (78.3%) patients had an abnormal PSG. Half of the patients fulfilled criteria for sleep apnea-hypopnea syndrome (SAHS); rapid eye movement behavior disorder (RBD) was present in 37.5%. Characteristics associated with SAHS were age (p = 0.049) and body mass index (p = 0.016). Regarding RBD, age (p < 0.001), left motor onset (p = 0.047) and levodopa equivalent dose (p = 0.002) were the main predictors.
CONCLUSION
SAHS and RBD were the most frequent sleep disorders. Higher levodopa equivalent dose and body mass index appear to be risk factors for RBD and SAHS, respectively.
目的
帕金森病中的睡眠障碍非常常见。多导睡眠图（PSG）被认为是诊断的金标准。本研究的目的是评估通过多导睡眠图诊断的夜间睡眠障碍的患病率，并确定相关的临床因素。
方法
共纳入120例帕金森病患者。所有患者均接受了标准化的夜间单夜多导睡眠图检查。
结果
94例（78.3%）患者的多导睡眠图异常。一半的患者符合睡眠呼吸暂停低通气综合征（SAHS）的标准；快速眼动睡眠行为障碍（RBD）的发生率为37.5%。与SAHS相关的特征是年龄（p = 0.049）和体重指数（p = 0.016）。关于RBD，年龄（p < 0.001）、左侧运动起病（p = 0.047）和左旋多巴等效剂量（p = 0.002）是主要预测因素。
结论
SAHS和RBD是最常见的睡眠障碍。较高的左旋多巴等效剂量和体重指数似乎分别是RBD和SAHS的危险因素。
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