Qian H, Feng J, Cui H, Gao B, Qi G, Fu T, Wei P, Fu Z
Gynecologic Oncology Research Laboratory, People's Hospital, Beijing Medical University, People's Republic of China.
Gynecol Oncol. 1992 Nov;47(2):216-22. doi: 10.1016/0090-8258(92)90109-v.
Forty-eight cases subjected to radioimmunoimaging (RII) by intraperitoneal injection with 131I-C0C183B2 monoclonal antibody (MAb) prepared in our laboratory were studied. Thirteen of 14 cases of proved primary ovarian carcinoma were positive. In 11 follow-up cases of ovarian carcinoma after initial surgery and chemotherapy, 5 recurrences were positive and 6 cases without recurrence were negative; all were confirmed histopathologically after a second operation. One false negative was ovarian mucinous adenocarcinoma, which also negatively stained with C0C183B2 by the peroxidase anti-peroxidase method. Twenty of 23 cases of nonepithelial or metastatic carcinoma of the ovary, benign tumors, and benign diseases were negative. The sensitivity and specificity were 94.7 and 89.7%, respectively. If patients had complications with ascites, the MAb which positively stained with the cancer cells in the ascites was chosen for RII. For follow-up cases PAP staining with the tumor tissue from the initial surgery and the MAb should be done before RII. These are the principal factors that increase the positive rate and accuracy of RII. The intraperitoneal route seems to be a valuable method for clinical staging and tumor localization as well as for follow-up use.
对48例经腹腔注射我院制备的131I - C0C183B2单克隆抗体（MAb）进行放射免疫显像（RII）的患者进行了研究。14例经证实的原发性卵巢癌患者中有13例呈阳性。在11例初次手术和化疗后的卵巢癌随访病例中，5例复发患者呈阳性，6例未复发患者呈阴性；所有病例均在二次手术后经组织病理学证实。1例假阴性为卵巢黏液腺癌，其通过过氧化物酶抗过氧化物酶法对C0C183B2也呈阴性染色。23例卵巢非上皮性或转移性癌、良性肿瘤及良性疾病患者中有20例呈阴性。敏感性和特异性分别为94.7%和89.7%。若患者有腹水并发症，则选择对腹水中癌细胞呈阳性染色的MAb进行RII。对于随访病例，在RII前应使用初次手术的肿瘤组织进行PAP染色并使用MAb。这些是提高RII阳性率和准确性的主要因素。腹腔途径似乎是一种用于临床分期、肿瘤定位以及随访的有价值的方法。
