骨形态发生蛋白受体的信号转导
Signal transduction of bone morphogenetic protein receptors.
作者信息
Nohe Anja, Keating Eleonora, Knaus Petra, Petersen Nils O
机构信息
Department of Chemistry, University of Western Ontario, N6A1B7 London, Canada.
出版信息
Cell Signal. 2004 Mar;16(3):291-9. doi: 10.1016/j.cellsig.2003.08.011.
Bone morphogenetic proteins (BMPs) play a crucial role during all stages of embryonic development. Although only two major signaling pathways have been characterized (the p38 and Smad pathways), the BMP signaling is complex and includes several negative feedback mechanisms. This article reviews the current state of BMP receptor signaling and provides a summary of the crosstalk of the BMP receptor pathway with other major signaling pathways.
骨形态发生蛋白（BMPs）在胚胎发育的各个阶段都起着至关重要的作用。尽管目前仅鉴定出两条主要的信号通路（p38和Smad通路），但BMP信号传导是复杂的，并且包括几种负反馈机制。本文综述了BMP受体信号传导的当前状态，并总结了BMP受体通路与其他主要信号通路的相互作用。
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