School of Stomatology, Jinan University, Guangzhou, 510632, China.
Clinical Research Center, Clifford Hospital, Guangzhou, 511495, China.
BMC Oral Health. 2024 Mar 1;24(1):290. doi: 10.1186/s12903-024-04013-2.
Ensuring the quantity, quality, and efficacy of human dental mesenchymal stem cells (MSCs) has become an urgent problem as their applications increase. Growth factors (GFs) have low toxicity, good biocompatibility, and regulate stem cell survival and differentiation. They bind to specific receptors on target cells, initiating signal transduction and triggering biological functions. So far, relatively few studies have been conducted to summarize the effect of different GFs on the application of dental MSCs. We have reviewed the literature from the past decade to examine the effectiveness and mechanism of applying one or multiple GFs to human dental MSCs. Our review is based on the premise that a single dental MSC cannot fulfill all applications and that different dental MSCs react differently to GFs.
A search for published articles was carried out using the Web of Science core collection and PubMed. The study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines. This review considered studies from 2014 to 2023 that examined the effects of GFs on human dental MSCs. The final selection of articles was made on the 15th of July 2023.
Three thousand eight hundred sixty-seven pieces of literature were gathered for this systematic review initially, only 56 of them were selected based on their focus on the effects of GFs during the application of human dental MSCs. Out of the 56, 32 literature pieces were focused on a single growth factor while 24 were focused on multiple growth factors. This study shows that GFs can regulate human dental MSCs through a multi-way processing manner.
Multimodal treatment of GFs can effectively regulate human dental MSCs, ensuring stem cell quality, quantity, and curative effects.
随着人类牙源性间充质干细胞（MSCs）应用的增加，确保其数量、质量和功效成为当务之急。生长因子（GFs）具有低毒性、良好的生物相容性，可调节干细胞的存活和分化。它们与靶细胞上的特定受体结合，启动信号转导并触发生物学功能。到目前为止，很少有研究总结不同 GFs 对牙源性 MSCs 应用的影响。我们回顾了过去十年的文献，研究了应用一种或多种 GFs 对人牙源性 MSCs 的效果及其机制。我们的综述基于以下前提，即单个牙源性 MSC 不能满足所有应用，并且不同的牙源性 MSC 对 GFs 的反应不同。
使用 Web of Science 核心合集和 PubMed 对已发表的文章进行检索。本研究遵循系统评价和荟萃分析的首选报告项目（PRISMA 2020）指南进行。本综述考虑了 2014 年至 2023 年期间研究 GFs 对人牙源性 MSCs 影响的研究。最终的文章选择于 2023 年 7 月 15 日完成。
最初系统综述共收集了 3867 篇文献，仅根据它们对 GFs 在人牙源性 MSCs 应用过程中的影响进行了选择，最终有 56 篇被选中。其中 32 篇文献集中研究了单一生长因子，24 篇文献集中研究了多种生长因子。本研究表明，GFs 可以通过多种方式调节人牙源性 MSCs。
GFs 的多模态治疗可以有效调节人牙源性 MSCs，保证干细胞的质量、数量和疗效。
