Pickens D R
Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2675.
Invest Radiol. 1992 Dec;27 Suppl 2:S12-7. doi: 10.1097/00004424-199212002-00003.
Quantitation of perfusion and diffusion in tissues using magnetic resonance imaging (MRI) techniques is an active area of research in many laboratories. Several different approaches have been taken to address the problem of determining microcirculatory flow or perfusion in the body with MRI. Methods have been developed that depend on pulse sequence designs to sensitize the acquisitions to proton movement that is part of physiologic perfusion. Other methods that are being studied take a different approach by using injected MR contrast agents coupled with high temporal resolution acquisitions to produce time-density curves that can be related to perfusion in the tissues of interest. Yet other approaches use blood as the tracer itself to provide a means of determining perfusion. All of these techniques and others provide quantitative information related to microcirculatory flow in tissues.
利用磁共振成像（MRI）技术对组织中的灌注和扩散进行定量分析，是许多实验室研究的一个活跃领域。人们已经采用了几种不同的方法来解决用MRI确定体内微循环血流或灌注的问题。已经开发出了一些方法，这些方法依赖于脉冲序列设计，以使采集对作为生理灌注一部分的质子运动敏感。正在研究的其他方法则采用不同的途径，即使用注入的磁共振造影剂并结合高时间分辨率采集，以生成可与感兴趣组织中的灌注相关的时间-密度曲线。还有其他方法将血液本身用作示踪剂，以提供一种确定灌注的手段。所有这些技术以及其他技术都提供了与组织中微循环血流相关的定量信息。
