Chen L T, Phelps C P, Bryant M W, Chen M E
Department of Anatomy, College of Medicine, University of South Florida, Tampa, FL 33612, USA.
J Submicrosc Cytol Pathol. 2003 Jul;35(3):303-7.
Central venous catheters are commonly used in clinics for the administration of infusion therapy and total parenteral nutrition. Catheter occlusion is the most common noninfectious complication associated with the long-term use of such devices. The cause of catheter occlusion is the formation of a tissue sleeve around the catheter. In this study, a rat model was used to investigate the effects of integrin antagonist peptide on the growth of the tissue sleeve around the jugular catheters. When integrin antagonist peptide was injected subcutaneously, twice daily, for 3 days, at a dosage of 10 mg/kg of body weight/day, the growth of the tissue sleeve was reduced by 40%, as compared to rats injected with saline or control peptide. Morphological study of the tissue sleeve indicated that catheter-related damage to the nearby endothelial cells was associated with the adhesion of platelets and leukocytes to the injured endothelium and accumulation of fibrin in the vicinity. This proposed sequence of events resulted in an increase in the thickness of the tissue sleeve and changes in sleeve transparency.
中心静脉导管在临床上常用于输注治疗和全胃肠外营养。导管堵塞是长期使用此类装置最常见的非感染性并发症。导管堵塞的原因是导管周围形成组织套。在本研究中，使用大鼠模型研究整合素拮抗剂肽对颈静脉导管周围组织套生长的影响。当以10mg/kg体重/天的剂量每天皮下注射整合素拮抗剂肽两次，持续3天时，与注射生理盐水或对照肽的大鼠相比，组织套的生长减少了40%。对组织套的形态学研究表明，导管对附近内皮细胞的损伤与血小板和白细胞粘附于受损内皮以及附近纤维蛋白的积累有关。这一推测的事件序列导致组织套厚度增加和套透明度改变。
