Dogan Abdullah, Tunc Bahattin, Ergene Oktay, Ozaydin Mehmet, Nazli Cem, Altinbas Ahmet, Gedikli Omer
Department of Cardiology, Suleyman Demirel University, Medical School, Isparta, Turkey.
Int J Cardiovasc Imaging. 2003 Dec;19(6):465-71. doi: 10.1023/b:caim.0000004339.30038.8d.
Since the role of fibrinolytic activity is unclear in coronary artery ectasia, we investigated the entire fibrinolytic activity by a new test, global fibrinolytic capacity (GFC) in the ectasia patients.
Thirty-four ectasia patients (18 male, mean age: 58 +/- 8 years) presenting with acute coronary syndrome and 25 controls (14 male, mean age: 56 +/- 9 years) with normal coronary artery were evaluated. GFC, D-dimer and other hemostatic factors were assessed. Clinical characteristics were comparable in both groups. Serum GFC (4.6 +/- 2.1 vs. 3.1 +/- 2.1 microg/ml, p = 0.03) and D-dimer levels (0.69 +/- 0.42 vs. 0.41 +/- 0.38 ng/ml, p = 0.02, respectively) were significantly higher in ectasia patients than in controls. They were also higher in subgroup of patients with myocardial infarction (four patients) compared with other ectasia patients and controls (p = 0.04, 0.01, respectively). Other hemostatic factors were not different in both groups. GFC was correlated with D-dimer (r = 0.76, p = 0.01).
Our results suggest that fibrinolytic system activation may develop in ectasia patients with acute coronary syndrome. It can be induced by thrombus formation in ectatic segment of coronary artery.
由于纤溶活性在冠状动脉扩张中的作用尚不清楚，我们通过一项新的检测方法——整体纤溶能力（GFC），对冠状动脉扩张患者的整体纤溶活性进行了研究。
对34例表现为急性冠状动脉综合征的冠状动脉扩张患者（18例男性，平均年龄：58±8岁）和25例冠状动脉正常的对照组患者（14例男性，平均年龄：56±9岁）进行了评估。评估了GFC、D - 二聚体及其他止血因子。两组的临床特征具有可比性。冠状动脉扩张患者的血清GFC（4.6±2.1 vs. 3.1±2.1微克/毫升，p = 0.03）和D - 二聚体水平（分别为0.69±0.42 vs. 0.41±0.38纳克/毫升，p = 0.02）显著高于对照组。与其他冠状动脉扩张患者及对照组相比，心肌梗死患者亚组（4例患者）的GFC和D - 二聚体水平也更高（分别为p = 0.04，0.01）。两组的其他止血因子无差异。GFC与D - 二聚体相关（r = 0.76，p = 0.01）。
我们的结果表明，急性冠状动脉综合征的冠状动脉扩张患者可能发生纤溶系统激活。它可能由冠状动脉扩张段的血栓形成所诱导。
