Martiney J A, Berman J W, Brosnan C F
Department of Pathology, Albert Einstein College of Medicine, New York, NY.
J Neuroimmunol. 1992 Dec;41(2):167-76. doi: 10.1016/0165-5728(92)90067-u.
The chronic effects of human recombinant IL-1 (hrIL-1) on the specialized vasculature of the central nervous system (CNS) and on the CNS itself have been examined over a 35-day period in the rabbit retina. A single intraocular injection of physiological levels of hrIL-1 (300 units) induced a biphasic inflammatory reaction with well-defined acute and chronic phases in the challenged eye. Quantitative histopathological examination of the vascularized portion of the retina in the IL-1-challenged eye documented a persistent mononuclear (MN) cell response that peaked 7-14 days post-challenge. Included in the MN cell count were perivascular plasma cells. Elevated protein levels in the vitreous persisted throughout the time points studied and alterations in vascular permeability of the epiretinal vessels were demonstrated by tracer leakage at 2 weeks post-challenge. The results show that exposure of the CNS-vasculature to IL-1 induces long-lasting inflammatory changes typical of a chronic inflammatory reaction.
在长达35天的时间里，研究了重组人白细胞介素-1（hrIL-1）对家兔视网膜中枢神经系统（CNS）的特殊脉管系统以及CNS本身的慢性影响。向眼内单次注射生理水平的hrIL-1（300单位），在受试眼中诱发了具有明确急性期和慢性期的双相炎症反应。对IL-1受试眼视网膜血管化部分进行的定量组织病理学检查表明，存在持续的单核（MN）细胞反应，该反应在激发后7-14天达到峰值。MN细胞计数中包括血管周围浆细胞。在所研究的各个时间点，玻璃体内蛋白质水平持续升高，并且在激发后2周通过示踪剂渗漏证明视网膜前血管的血管通透性发生了改变。结果表明，CNS脉管系统暴露于IL-1会诱发慢性炎症反应典型的持久炎症变化。
