Martiney J A, Cuff C, Litwak M, Berman J, Brosnan C F
Laboratory of Microbial Pathogenesis, The Picower Institute for Medical Research, Manhasset, NY 11030, USA.
Neurochem Res. 1998 Mar;23(3):349-59. doi: 10.1023/a:1022457500700.
Cytokines play an essential role as mediators of the immune response. They usually function as part of a network of interactive signals that either activate, enhance, or inhibit the ensuing reaction. An important contribution of this cytokine cascade is the induction of an inflammatory response that recruits and activates subsets of leukocytes that function as effector cells in the response to the sensitizing antigen. Proinflammatory cytokines activate endothelial cells (EC) to express adhesion molecules and induce the release of members of the chemokine family, thus focusing and directing the inflammatory response to sites of antigen recognition. However, the vasculature of the central nervous system (CNS) is highly specialized and restricts the access of components of the immune system to the CNS compartment. In this review, we address the question as to whether endothelial cells in the CNS respond differently to specific cytokines known to induce either a proinflammatory effect or a regulatory effect in systemic vascular beds.
细胞因子作为免疫反应的介质发挥着至关重要的作用。它们通常作为相互作用信号网络的一部分发挥作用，这些信号要么激活、增强，要么抑制后续反应。这种细胞因子级联反应的一个重要作用是诱导炎症反应，该反应募集并激活白细胞亚群，这些白细胞亚群在对致敏抗原的反应中起效应细胞的作用。促炎细胞因子激活内皮细胞（EC）以表达黏附分子并诱导趋化因子家族成员的释放，从而将炎症反应聚焦并引导至抗原识别部位。然而，中枢神经系统（CNS）的脉管系统高度特化，限制了免疫系统成分进入CNS腔室。在本综述中，我们探讨了一个问题，即中枢神经系统中的内皮细胞对已知在全身血管床中诱导促炎作用或调节作用的特定细胞因子的反应是否不同。
