Zhang Huanxiang, Vutskits Laszlo, Pepper Michael S, Kiss Jozsef Z
Department of Morphology, University Medical Center, University of Geneva Medical School, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland.
J Cell Biol. 2003 Dec 22;163(6):1375-84. doi: 10.1083/jcb.200308040.
Migration of undifferentiated neural progenitors is critical for the development and repair of the nervous system. However, the mechanisms and factors that regulate migration are not well understood. Here, we show that vascular endothelial growth factor (VEGF)-A, a major angiogenic factor, guides the directed migration of neural progenitors that do not display antigenic markers for neuron- or glia-restricted precursor cells. We demonstrate that progenitor cells express both VEGF receptor (VEGFR) 1 and VEGFR2, but signaling through VEGFR2 specifically mediates the chemotactic effect of VEGF. The expression of VEGFRs and the chemotaxis of progenitors in response to VEGF require the presence of fibroblast growth factor 2. These results demonstrate that VEGF is an attractive guidance cue for the migration of undifferentiated neural progenitors and offer a mechanistic link between neurogenesis and angiogenesis in the nervous system.
未分化神经祖细胞的迁移对于神经系统的发育和修复至关重要。然而，调节迁移的机制和因素尚未完全明确。在此，我们表明血管内皮生长因子（VEGF）-A，一种主要的血管生成因子，可引导未显示神经元或胶质细胞限制性前体细胞抗原标志物的神经祖细胞进行定向迁移。我们证明祖细胞同时表达VEGF受体（VEGFR）1和VEGFR2，但通过VEGFR2的信号传导特异性介导了VEGF的趋化作用。VEGFR的表达以及祖细胞对VEGF的趋化作用需要成纤维细胞生长因子2的存在。这些结果表明VEGF是未分化神经祖细胞迁移的一种有吸引力的引导信号，并为神经系统中神经发生与血管生成之间提供了一种机制联系。
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