Wada Shigehito, Yue Lihua, Furuta Isao
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
Oral Oncol. 2004 Feb;40(2):164-9. doi: 10.1016/s1368-8375(03)00146-5.
We evaluated the prognostic significance of p34cdc2 expression in 50 tongue squamous cell carcinomas (SCC) using immunohistochemical methods. The p34cdc2 protein was expressed in 33 cases of 50 tumor tissues (66.0%), compared with 15 cases of 42 controlled epithelia (35.7%). The expression of p34cdc2 was significantly correlated with the histological grade of tongue carcinoma (P<0.01). In addition, on evaluation of prognosis of tumor, the p34cdc2 protein was overexpressed in recurrent tumors or in those with lymph node metastasis. Statistics showed a significant reduction in the 5-year accumulative survival rate of p34cdc2 positive cases compared with p34cdc2 negative cases (P<0.01). Namely, the p34cdc2 positive patients had worse prognosis. The results suggested that the expression of p34cdc2 suited to the histological grade might reflect the malignant degree of tongue carcinoma biologically. Therefore, the evaluation of p34cdc2 expression was of benefit in elucidating the nature of tumor malignancy and the prognostic prediction of tongue SCC.
我们采用免疫组化方法评估了50例舌鳞状细胞癌（SCC）中p34cdc2表达的预后意义。在50例肿瘤组织中，有33例（66.0%）表达p34cdc2蛋白，而在42例对照上皮组织中，有15例（35.7%）表达。p34cdc2的表达与舌癌的组织学分级显著相关（P<0.01）。此外，在评估肿瘤预后时，p34cdc2蛋白在复发肿瘤或有淋巴结转移的肿瘤中过度表达。统计学显示，与p34cdc2阴性病例相比，p34cdc2阳性病例的5年累积生存率显著降低（P<0.01）。也就是说，p34cdc2阳性患者的预后较差。结果表明，与组织学分级相适应的p34cdc2表达可能从生物学角度反映舌癌的恶性程度。因此，评估p34cdc2表达有助于阐明肿瘤恶性的本质以及舌SCC的预后预测。
