CDK1表达在口腔鳞状细胞癌中的临床意义。

The clinical significance of CDK1 expression in oral squamous cell carcinoma.

作者信息

Chen Xin, Zhang Feng-He, Chen Qiao-Er, Wang Yuan-Yin, Wang Yin-Long, He Jia-Cai, Zhou Jian

机构信息

Department of Oral and Maxillofacial Surgery, College and Hospital of Stomatology, Shandong University, China,

出版信息

Med Oral Patol Oral Cir Bucal. 2015 Jan 1;20(1):e7-12. doi: 10.4317/medoral.19841.

OBJECTIVES

To evaluate the clinical significance of cyclin-dependent kinase 1 (CDK1) in 77 oral squamous cell carcinomas (OSCC) using immunohistochemical methods.

STUDY DESIGN

Immunohistochemical expression of CDK1 was compared with various clinicopathological features in 77 OSCC and 60 controlled epithelia adjacent to the tumours. In addition, correlation of CDK1 expression and prognostic and the 5-year accumulative survival rate of OSCC were investigated.

RESULTS

The CDK1 protein was expressed in 52 cases of 77 tumor tissues (67.5%), compared with 21 cases of 60 controlled (35.0%). The expression of CDK1 was significantly correlated with the histological grade of OSCC (P<0.05). The CDK1 protein was over-expressed in recurrent tumors or in those with lymph node metastasis. Statistical analysis showed a significant reduction in the 5-year accumulative survival rate in CDK1 positive cases compared with CDK1 negative cases (P<0.05). Namely, the CDK1 positive patients had poor prognosis.

CONCLUSIONS

The expression of CDK1 might serve as malignant degree and prognostic markers for the survival of OSCC.

目的

采用免疫组化方法评估细胞周期蛋白依赖性激酶1（CDK1）在77例口腔鳞状细胞癌（OSCC）中的临床意义。

研究设计

比较77例OSCC及60例肿瘤旁对照上皮组织中CDK1的免疫组化表达与各种临床病理特征。此外，研究CDK1表达与OSCC预后及5年累积生存率的相关性。

结果

77例肿瘤组织中有52例（67.5%）表达CDK1蛋白，而60例对照组织中有21例（35.0%）表达。CDK1的表达与OSCC的组织学分级显著相关（P<0.05）。CDK1蛋白在复发肿瘤或有淋巴结转移的肿瘤中过度表达。统计分析显示，与CDK1阴性病例相比，CDK1阳性病例的5年累积生存率显著降低（P<0.05）。即CDK1阳性患者预后较差。