导致酿酒酵母对新型1,3-β-葡聚糖合酶抑制剂阿波坎丁C产生选择性抗性的FKS1突变
FKS1 mutations responsible for selective resistance of Saccharomyces cerevisiae to the novel 1,3-beta-glucan synthase inhibitor arborcandin C.
作者信息
Ohyama Takao, Miyakoshi Shunichi, Isono Fujio
机构信息
Lead Discovery Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan.
出版信息
Antimicrob Agents Chemother. 2004 Jan;48(1):319-22. doi: 10.1128/AAC.48.1.319-322.2004.
Abstract
Arborcandin C is a novel antibiotic with potent antifungal activity that inhibits 1,3-beta-glucan synthase in fungi. We examined spontaneous Saccharomyces cerevisiae mutants which are selectively resistant to arborcandin C and revealed that a single amino acid replacement in Fks1p of Asn(470) with Lys or of Leu(642) with Ser confers selective resistance on Fks1p mutants.
摘要
乔木霉素C是一种新型抗生素，具有强大的抗真菌活性，可抑制真菌中的1,3-β-葡聚糖合酶。我们研究了对乔木霉素C具有选择性抗性的酿酒酵母自发突变体，发现Fks1p中Asn(470)被Lys取代或Leu(642)被Ser取代的单个氨基酸替换赋予了Fks1p突变体选择性抗性。
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