Thomas Mark R, Rafferty Gerrard F, Limb Elizabeth S, Peacock Janet L, Calvert Sandra A, Marlow Neil, Milner Anthony D, Greenough Anne
Department of Child Health, Guy's King's & St. Thomas' Medical School, King's College Hospital, London, UK.
Am J Respir Crit Care Med. 2004 Apr 1;169(7):868-72. doi: 10.1164/rccm.200310-1425OC. Epub 2003 Dec 23.
Prematurely born infants supported by conventional ventilation (CV) frequently have abnormal pulmonary function when assessed in childhood. The aim of this study was to test the hypothesis that infants who were randomly assigned to high-frequency oscillatory ventilation would have superior pulmonary function at follow-up compared with those who received CV (UK Oscillation Study). Infants from 12 trial centers were recruited for pulmonary function testing at a single center. Seventy-six infants, of a mean gestational age 26.4 weeks, were studied after sedation with chloral hydrate at between 11 and 14 months of age, corrected for prematurity. Infants assigned to CV had similar pulmonary function compared with those assigned to high-frequency oscillatory ventilation, with mean (SD) results as follows: functional residual capacity measured by whole-body plethysmography, 26.9 (6.3) versus 26.5 (6.4) ml/kg; functional residual capacity measured by helium dilution, 24.1 (5.4) versus 23.5 (5.7) ml/kg; inspiratory airway resistance, 3.3 (1.3) versus 3.4 (1.6) kPa. second. L; expiratory airway resistance, 4.4 (2.8) versus 4.1 (2.5) kPa. second. L; respiratory rate, 31.2 (6.0) versus 33.9 (8.0) breaths/minute. We conclude that early use of high-frequency oscillatory ventilation in very preterm infants appears to offer no advantage over CV in terms of pulmonary function at follow-up.
采用传统通气（CV）支持的早产婴儿在儿童期接受评估时，肺功能常常异常。本研究的目的是检验以下假设：与接受CV的婴儿相比，随机分配接受高频振荡通气的婴儿在随访时肺功能更优（英国振荡研究）。来自12个试验中心的婴儿被招募到一个中心进行肺功能测试。76名平均胎龄26.4周的婴儿在11至14个月龄（矫正早产）时用氯水合氯醛镇静后接受研究。分配到CV组的婴儿与分配到高频振荡通气组的婴儿肺功能相似，平均（标准差）结果如下：通过全身体积描记法测量的功能残气量，分别为26.9（6.3）和26.5（6.4）ml/kg；通过氦稀释法测量的功能残气量，分别为24.1（5.4）和23.5（5.7）ml/kg；吸气气道阻力，分别为3.3（1.3）和3.4（1.6）kPa·秒·L；呼气气道阻力，分别为4.4（2.8）和4.1（2.5）kPa·秒·L；呼吸频率，分别为31.2（6.0）和33.9（8.0）次/分钟。我们得出结论，在随访时，对于极早产婴儿，早期使用高频振荡通气在肺功能方面似乎并不比CV更具优势。
